Bio

I am a Research Fellow in the Department of Physiology and Biomedical Engineering at Mayo Clinic in Arizona.

My academic journey began with a PhD in School of Life Sciences, University of Science and Technology of China, where my research focused on the mechanisms and regulation of meiosis from 2009 to 2015. Following this, I worked as a Postdoctoral Researcher at Institute of Molecular Genetics, Division BIOCEV, Academy of Sciences of the Czech Republic, Prague, Czech Republic, from 2016 to 2018. During this time, I conducted research on hybrid sterility and meiotic recombination in mouse inter-species hybrids. In 2018, I joined department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, where I expanded my research area from human reproduction to diabetes. I implemented a droplet-based, single-cell RNA-seq method to determine the transcriptomes of individual pancreatic cells from mouse and human.

• 08.2020-Present: Research Fellow, Department of Physiology and Biomedical Engineering, Mayo Clinic, Scottsdale, Arizona, US.
• 08.2018-08.2020: Post Doctoral Scholar. Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio, US.
• 04.2016-06.2018: Postdoc. Institute of Molecular Genetics, Division BIOCEV, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

• Novel epigenetic regulators in metabolic diseases and chronic inflammation:
  Using both beta cells and mouse models, investigates the epigenomic regulation of cellular dysfunction in diabetes and metabolic diseases, and studies the fundamental mechanisms of transcription and chromatin biology.
• Single-cell Transcriptomics, Epigenomics and Proteomics:
  Much of the effort is focused on development and application of novel statistical methods and computational tools for understanding tissue function, including analysis of multi-omics datasets.

• Bromodomain containing 9 (BRD9) regulates macrophage inflammatory responses by potentiating glucocorticoid receptor activity
  Liu Wang,Tae Gyu Oh, Jason Magida, Gabriela Estepa, SM Bukola Obayomi, Ling-Wa Chong, Jovylyn Gatchalian, Ruth T Yu, Annette R Atkins, Diana Hargreaves, Michael Downes, Zong Wei, Ronald M Evans (2021) Proceedings of the National Academy of Sciences, e2109517118.

  Link

• Exploring the trans‐cleavage activity of CRISPR‐Cas12a (cpf1) for the development of a universal electrochemical biosensor
  Yifan Dai, Rodrigo A Somoza, Liu Wang, Jean F Welter, Yan Li, Arnold I Caplan, Chung Chiun Liu (2019) Angewandte Chemie, 17560-17566.

  Link

• Cisplatin-induced DNA double-strand breaks promote meiotic chromosome synapsis in PRDM9-controlled mouse hybrid sterility
  Liu Wang, Barbora Valiskova, Jiri Forejt (2018) Elife, e42511.

  Link

• Editorial Board
  2023-Present: Human Fertility, Editorial Board Member.
• Guest Editorship
  2021-2023: Frontiers in Endocrinology, Guest Associate Editor, Research Topic: Application of Multi-omics Analysis in Gametogenesis and the Relevant Human Infertility Diseases.
• Journal Reviewer
  Frontiers in Endocrinology, Molecular Biology Reports, Reproduction in Domestic Animals, Genetic Testing and Molecular Biomarkers, Endocrine, PLOS ONE, Disease Markers, Frontiers in Genetics, Frontiers in Cardiovascular Medicine, Frontiers in Oncology, Genes & Genetic Systems, Frontiers in Reproductive Health,eLife,Human Fertility,Journal of Advanced Research

Python, R, Shell, C++, Perl

scRNA-seq, scATAC-seq, CUT&RUN,RNA-seq, ChIP-seq,Paired-Tag,ATAC-seq,CROP-seq

Dimensionality Reduction, Data Visualization

• 256wangliu AT gmail DOT com
• Liu_Wang_
• 13400 E. Shea Blvd, Scottsdale, AZ 85259