Bio

Dr. Wang received his Ph.D. from the School of Life Sciences at the University of Science and Technology of China, where he studied the genetic basis of human male infertility caused by meiotic defects. He subsequently completed postdoctoral training with Dr. Jiří Forejt at the Institute of Molecular Genetics, BIOCEV, Czech Academy of Sciences, investigating hybrid sterility and meiotic recombination in mouse interspecies hybrids. In 2018, Dr. Wang joined the Department of Genetics and Genome Sciences at Case Western Reserve University, where he expanded his research to pancreatic β-cell biology, genomics, and diabetes. He applied CROP-seq to investigate gene function and characterize pancreatic cell states in mouse and human tissues. At the Mayo Clinic, he further developed single-cell multiomic approaches for simultaneously profiling histone modifications and gene expression in pancreatic islets, while creating computational pipelines for large-scale multiomic data analysis. Dr. Wang's research integrates single-cell and spatial multiomics, computational genomics, and machine learning to understand the molecular mechanisms of diabetes and identify novel therapeutic targets.

• Epigenetic Regulation in Diabetes and Metabolic Disease
  Investigating how epigenetic mechanisms regulate pancreatic β-cell function and dysfunction in diabetes and other metabolic diseases using mouse models and human islets. This work aims to uncover the molecular mechanisms controlling gene regulation, chromatin dynamics, and disease progression.
• Single-Cell and Spatial Multiomics
  Developing and applying single-cell and spatial transcriptomic, epigenomic, and proteomic technologies to characterize cellular heterogeneity and gene regulatory networks in healthy and diseased tissues.
• Computational Genomics and Artificial Intelligence
  Developing computational methods and machine learning approaches for the integrative analysis of large-scale multiomic datasets to identify disease mechanisms and discover novel therapeutic targets.

• Single-Cell Multiomic Analysis of Human Islets Reveals Cell Type-Specific Epigenetic Regulation and Noncoding Genetic Risk in Type 2 Diabetes
  Liu Wang, Zong Wei (2026) #####.

  Link

• Developmental control of DNA damage responses in α- and β-cells shapes the selective β-cell susceptibility in diabetes
  Sneha S. Varghese, Alessandro Giovanni Hernandez-De La Peña, Liu Wang, Victor Ruiz, Wilma Tixi, Aparamita Pandey, Laura Anchondo, Amy Chiu, Xiwei Wu, Senta K. Georgia, Hung-Ping Shih, Zong Wei, Supriyo Bhattacharya, Sangeeta Dhawan. (2026) Diabetes.

  Link

• BET signaling and FXR signaling orchestrate to protect β cells
  Fritz Cayabyab, Jalan Tipirneni, David Chen, Jinhyuk Choi, Clarissa Tacto, Jie Wu, Liu Wang, Yeva Mirzakhanyan, Paul David Gershon, Harvey Perez, Kiyoka Kim, Sungsoon Fang, Eli Ipp, Lin-Feng Chen, Zong Wei, Eiji Yoshihara(2026) #####.

  Link

• Circadian entrainment of pancreatic islet function and of the pancreatic islet transcriptome is regulated by glucocorticoid signaling
  Satish K. Sen, Matthew R. Brown, Liu Wang, Jie Wu, Luhui Zhang, Tracy Her, Kuntol Rakshit, Amelia Mazzone, Alexandre Gaspar-Maia, Adrian Vella, Zong Wei, and Aleksey V. Matveyenko.2026 ###.

  Link

• NAD+ dependent deacetylase SIRT7 mediates vitamin D signaling to protect pancreatic β cells
  Jie Wu, Liu Wang, Xiaoqiang Sun, SM Bukola Obayomi, Zhuqing Li, Chunbo Ai, Aleksey V. Matveyenko, Zong Wei. 2026 ###.

  Link

• A molecular circuit regulates fate plasticity in emerging and adult AT2 cells
  Amitoj S Sawhney, Brian J Deskin, Junming Cai, Daniel Gibbard, Gibran Ali, Annika Utoft, Xianmei Qi, Aaron Olson, Hannah Hausman, Liberty Sabol, Shannon Holmberg, Ria Shah, Rachel Warren, Stijn De Langhe, Rui Benedito, Zintis Inde, Kristopher A Sarosiek, Evan Lemire, Adam L Haber, Liu Wang, Zong Wei, Douglas G Brownfield.(2025) Nature Communications.

  Link

• Heterogeneous enhancer states orchestrate β cell responses to metabolic stress
  Liu Wang , Jie Wu, Madeline Sramek, SM Bukola Obayomi, Peidong Gao, Yan Li, Aleksey V Matveyenko, Zong Wei(2024) Nature Communications,15(1):9361.

  Link

• Bromodomain containing 9 (BRD9) regulates macrophage inflammatory responses by potentiating glucocorticoid receptor activity
  Liu Wang,Tae Gyu Oh, Jason Magida, Gabriela Estepa, SM Bukola Obayomi, Ling-Wa Chong, Jovylyn Gatchalian, Ruth T Yu, Annette R Atkins, Diana Hargreaves, Michael Downes, Zong Wei, Ronald M Evans (2021) Proceedings of the National Academy of Sciences, e2109517118.

  Link

• Exploring the trans‐cleavage activity of CRISPR‐Cas12a (cpf1) for the development of a universal electrochemical biosensor
  Yifan Dai, Rodrigo A Somoza, Liu Wang, Jean F Welter, Yan Li, Arnold I Caplan, Chung Chiun Liu (2019) Angewandte Chemie, 17560-17566.

  Link

• Cisplatin-induced DNA double-strand breaks promote meiotic chromosome synapsis in PRDM9-controlled mouse hybrid sterility
  Liu Wang, Barbora Valiskova, Jiri Forejt (2018) Elife, e42511.

  Link

• Editorial Board
  2023-Present: Human Fertility, Associate Editor.
• Guest Editorship
  2021-2023: Frontiers in Endocrinology, Guest Associate Editor, Research Topic: Application of Multi-omics Analysis in Gametogenesis and the Relevant Human Infertility Diseases.
• Journal Reviewer
  Frontiers in Endocrinology, Molecular Biology Reports, Reproduction in Domestic Animals, Genetic Testing and Molecular Biomarkers, Endocrine, PLOS ONE, Disease Markers, Frontiers in Genetics, Frontiers in Cardiovascular Medicine, Frontiers in Oncology, Genes & Genetic Systems, Frontiers in Reproductive Health,eLife,Human Fertility,Journal of Advanced Research
• Abstract Reviewer
  Mayo Clinic 5th Annual Research Allied Health Symposium, Abstract Reviewer, Mayo Clinic, 2025
• Grant Reviewer
  Grant Reviewer for Breakthrough T1D, 2025
• Member
  The Human Islet Research Network (HIRN), CBDS. 2025--current
• Presentations
• 2026 HIRN Annual Meeting.Poster Presentation. Washington, DC 2026.
• ADA 2026 Annual Meeting, American Diabetes Association. New Orleans, LA. Poster Presentation. 2026.
• 2025 HIRN Annual Meeting.Oral Presentation. 2025.
• Mayo Arizona Research Synergy meeting (MARS).Mayo Clinic Arizona, Phoenix, AZ. Oral Presentation. 2025.
• ASHG 2025 Annual Meeting, American Society of Human Genetics. Boston, MA. Poster Presentation. 2025.
• The Western Region Islet Study Group (WRISG) meeting. Pacific Grove, California. Oral Presentation. 2024.
• Summer School on RNA-protein interactions RNA Structure and Biology workshop. CEITEC MU, University Campus Bohunice, Kamenice 5, Brno, Czech Republic. Poster Presentation. 2017.

HIRN Data Scholars Leveraging Multi-Modal Human Islet Research Network Knowledge (LINK) Award:

Human Islet Research Network (HIRN), 2025-2026

IIDP Data Resource - Trainee Scholar Award (DRTSA):

Integrated Islet Distribution Program (IIDP), 2025-2026

DMM Conference Travel Grant:

Company of Biologists, 2024

• Wang.Liu@mayo.edu
• 13400 E. Shea Blvd, Scottsdale, AZ 85259