I am a Senior Research Fellow in the Department of Physiology and Biomedical Engineering at Mayo Clinic in Arizona.
My academic journey began with a PhD in School of Life Sciences, University of Science and Technology of China, where my research focused on the identification of genetic mutations that cause human male infertility by disrupting meiosis. Following this, I worked as a Postdoctoral Researcher under the mentorship of Dr.Jiří Forejt at Institute of Molecular Genetics, Division BIOCEV, Academy of Sciences of the Czech Republic, Prague, Czech Republic. During this time, I focused my research on hybrid sterility and meiotic recombination in mouse inter-species hybrids. In 2018, I joined department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University under the supervision of Dr.Yan Li, where I expanded my research area from human reproduction to beta cells, genomics and diabetes. I developed a droplet-based, single-cell RNA-seq method to determine the transcriptomes of individual pancreatic cells from mouse and human. At Mayo, I worked on developing a novel mulitomic platform which is able to measure histone modification and RNA from same single cells in mouse and human islets. In additional to the wet lab assays, I also developed the computational pipelines for analyzing the multiomic datasets. I apply AI and machine learning techniques to explore diabetes mechanisms and discover potential therapeutic targets.
Ph.D. in Genetics, 2015
School of Life Sciences, University of Science and Technology of China
R, Shell, Git, Python, Perl, C++
scRNA-seq, scATAC-seq, CUT&RUN,RNA-seq, ChIP-seq,Paired-Tag,ATAC-seq,CROP-seq
Dimensionality Reduction, Data Visualization